An evaluation of glossitis begins with a history and physical examination.

Physical findings in someone with glossitis may include:

• Tongue swelling:
• Red tongue
• Red smooth tongue
• Hairy tongue
• Grooved tongue
• Tongue lesions:
• Tongue ulcer
• White patches on the tongue

The diagnosis of glossitis is made during physical exam. The underlying cause of glossitis is usually confirmed through testing

Tests that may be used to evaluate glossitis include:

• Complete blood count
• VDRL (test for syphilis)
• Serum vitamin B12 level
• Serum folate level
• Serum glucose testing
• Bacterial or fungal cultures from tongue scrapings
• Strep screen