Glioma Pain in Adults

Medications commonly used to control pain and inflammation in adults with glioma include:

• Acetaminophen
• Controls pain, but has no anti-inflammatory properties
• Nonsteroidal anti-inflammatory drugs:
• Aspirin
• Ibuprofen
• Naproxen
• Ketoprofen
• Narcotic pain medications:
• Require a doctor's prescription
• Generally reserved for moderate to severe pain or severe pain

• Acetaminophen decreases fever and pain, but does not help inflammation.
• Adult dosing is 2 regular strength (325 mg) every 4 hours or 2 extra-strength (500 mg) every 6 hours.
• Maximum dose is 4,000 mg per day.
• Avoid this drug if you have alcoholism, liver disease or an allergy to the drug. See the package instructions.
• Common brand names include Tylenol, Panadol, and many others.

• Aspirin decreases pain, fever and inflammation.
• It is a nonsteroidal anti-inflammatory medication (NSAID).
• Adult dosing is two regular strength (325 mg) every 4 hours with food.
• There are numerous products that contain aspirin.
• Follow the package instructions and NSAID precautions (below).

• Ibuprofen decreases pain, fever and inflammation.
• It is a nonsteroidal anti-inflammatory medication (NSAID).
• Adult dosing is 200-400 mg every 4-6 hours.
• Do not exceed 1,200 mg per day without a doctor's recommendation.
• Brand names include Advil, Motrin and Nuprin.
• Follow the package instructions and NSAID precautions (below).

• Naproxen decreases pain, fever and inflammation.
• It is a nonsteroidal anti-inflammatory medication (NSAID).
• Adult dosing is 200 or 220 mg twice a day with food.
• Do not exceed 500 mg per day.
• Its brand name is Aleve.
• Follow the package instructions and NSAID precautions (below).

• Ketoprofen decreases pain, fever and inflammation.
• It is a nonsteroidal anti-inflammatory medication (NSAID).
• Adult dosing is 12.5 mg every 4-6 hours with food.
• Do not exceed 75 mg per day.
• Its brand name is Orudis KT.
• Follow the package instructions and NSAID precautions (below).

• Avoid using alcohol when taking any of these medications.
• Do not mix prescription and non-prescription NSAIDS unless directed to do so by your doctor.
• NSAIDS can interact with other blood thinners, such as Coumadin, and cause bleeding complications.
• Ask your doctor before using an NSAID if you are pregnant or breastfeeding.
• Ask your doctor before using an NSAID if you have a history of:
• Allergy to aspirin
• Asthma
• Peptic ulcer disease
• Stomach ulcers
• Esophageal ulcers
• Bleeding problems
• Liver disease
• Kidney disease

Last Updated: Dec 14, 2010 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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