Symptoms can vary with the location of the glioblastoma multiforme in the brain:

• Frontal lobe:
• Gradual changes in mood
• Gradual changes in personality
• Paralysis on one side of the body
• Temporal lobe:
• Problems with coordination
• Problems with speech
• Problems with memory
• Parietal lobe:
• Problems with sensation
• Problems with writing
• Problems with fine motor skills
• Cerebellum:
• Problems with coordination
• Problems with balance
• Occipital lobe:
• Problems with vision
• Visual hallucinations

The most common symptoms of glioblastoma multiforme include:

• Headache:
• Slowly worsening episodes
• Pain may be worse in the morning
• Pain may increase during coughing
• Symptoms that may accompany the headache:
• Nausea
• Vomiting

Additional symptoms of glioblastoma multiforme may include:

• Change in vision
• Double vision
• Confusion
• Dizziness
• Difficulty speaking
• Difficulty walking
• Hearing loss
• Memory loss
• Numbness in one arm or leg:
• Arm numbness (unilateral)
• Leg numbness (unilateral)
• Arm and leg numbness (unilateral)
• Weakness in one arm or leg:
• Arm weakness (unilateral)
• Leg weakness (unilateral)
• Arm and leg weakness (unilateral)

Less common symptoms are:

• Seizures
• Personality changes
• Unusual behavior