Folate Deficiency Underlying Cause
Folate is needed for the cell to make DNA, which acts as the blue print for activities inside the cell. Without folate or vitamin B12, the cell does not mature, and cannot perform normal functions. The effect on blood cells results in lower than normal levels of red blood cells in the bloodstream.
Causes of megaloblastic anemia include:
- Alcohol abuse
- The surgical removal of all or part of the stomach
- Gastric bypass surgery (bariatric surgery)
- Intestinal malabsorption
- Pernicious anemia
- Poor nutrition
- Zollinger-Ellison syndrome
- Medication side effects:
Continue to Folate Deficiency Anatomy
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- Bain BJ. Pathogenesis and pathophysiology of anemia in HIV infection. Curr Opin Hematol. 1999 Mar;6(2):89-93. 
- Wickramasinghe SN. The wide spectrum and unresolved issues of megaloblastic anemia. Semin Hematol. 1999 Jan;36(1):3-18.