Stephen J. Schueler, M.D.

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Folate Deficiency Underlying Cause

Folate is needed for the cell to make DNA, which acts as the blue print for activities inside the cell. Without folate or vitamin B12, the cell does not mature, and cannot perform normal functions. The effect on blood cells results in lower than normal levels of red blood cells in the bloodstream.

Causes of megaloblastic anemia include:

Continue to Folate Deficiency Anatomy

Last Updated: Aug 18, 2010 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Folate Deficiency References
  1. Arinzon Z, Fidelman Z, Peisakh A, Adunsky A. Folate status and folate related anemia: a comparative cross-sectional study of long-term care and post-acute care psychogeriatric patients. Arch Gerontol Geriatr. 2004 Sep-Oct;39(2):133-42. [15249150]
  2. Bain BJ. Diagnosis from the blood smear. N Engl J Med. 2005 Aug 4;353(5):498-507. [16079373]
  3. Bain BJ. Pathogenesis and pathophysiology of anemia in HIV infection. Curr Opin Hematol. 1999 Mar;6(2):89-93. [10088638]
  4. Wickramasinghe SN. The wide spectrum and unresolved issues of megaloblastic anemia. Semin Hematol. 1999 Jan;36(1):3-18. [9930565]
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