Stephen J. Schueler, M.D.

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Factor 8 Deficiency Overview

Another name for Factor 8 Deficiency is Hemophilia A.

What is hemophilia A?
Hemophilia A is an inherited bleeding disorder that primarily affects males. A person with hemophilia A is missing a protein called factor 8, which helps form blood clots. Normal blood coagulation requires the complex interaction of about 20 proteins, called clotting factors. Low levels of factor 8 result in prolonged blood clotting.

What are the symptoms of hemophilia A?
Symptoms of hemophilia A include prolonged bleeding, bleeding into the joints, joint swelling, joint pains, knee pain, bleeding gums, fatigue, nose bleeding, excessive bruising, blood in the stool, black stool, and a rash that looks like bruises or broken blood vessels.

How does the doctor treat hemophilia A?
Treatment for hemophilia A includes intravenous infusions of factor 8, fresh frozen plasma, desmopressin, and gene therapy.

Continue to Factor 8 Deficiency Risk Factors

Last Updated: Sep 4, 2010 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Factor 8 Deficiency References
  1. Dunn AL, Abshire TC. Recent advances in the management of the child who has hemophilia. Hematol Oncol Clin North Am. 2004 Dec;18(6):1249-76, viii. [15511615]
  2. Kern M, Blanchette V, Stain AM, Einarson TR, Feldman BM. Clinical and cost implications of target joints in Canadian boys with severe hemophilia A. J Pediatr. 2004 Nov;145(5):628-34. [15520762]
  3. Leissinger CA. Prevention of bleeds in hemophilia patients with inhibitors: emerging data and clinical direction. Am J Hematol. 2004 Oct;77(2):187-93. [15389908]
  4. Manco-Johnson M. Hemophilia management: optimizing treatment based on patient needs. Curr Opin Pediatr. 2005 Feb;17(1):3-6. [15659955]
  5. Plug I, van der Bom JG, Peters M, et al. Thirty years of hemophilia treatment in the Netherlands, 1972-2001. Blood. 2004 Dec 1;104(12):3494-500. [15308570]
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