Stephen J. Schueler, M.D.

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Factor 7 Deficiency Overview

What is factor 7 deficiency?
A person with factor 7 deficiency has a rare, hereditary blood clotting disorder that can result in severe bleeding. Normal blood coagulation requires the complex interaction of about 20 proteins, called clotting factors. Low levels of factor 7 result in prolonged blood clotting.

What are the symptoms of factor 7 deficiency?
Symptoms of factor 7 deficiency include bleeding into the joints, joint swelling, joint pain, bleeding gums, nosebleeds, and easy bruising. Women may experience heavy menstrual periods.

How does the doctor treat factor 7 deficiency?
There is no cure for factor 7 deficiency. Treatment for factor 7 deficiency may include fresh frozen plasma, factor 7 concentrate, and vitamin K. Patients should avoid aspirin, nonsteroidal anti-inflammatory medications, and other medications that can promote bleeding.

Continue to Factor 7 Deficiency Symptoms

Last Updated: Jan 11, 2011 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Factor 7 Deficiency References
  1. Barnett JM, Demel KC, Mega AE, Butera JN, Sweeney JD. Lack of bleeding in patients with severe factor VII deficiency. Am J Hematol. 2005 Feb;78(2):134-7. [15682417]
  2. Brummel Ziedins K, Rivard GE, Pouliot RL, Butenas S, Gissel M, Parhami-Seren B, Mann KG. Factor VIIa replacement therapy in factor VII deficiency. J Thromb Haemost. 2004 Oct;2(10):1735-44. [15456484]
  3. Muntean W. Fresh frozen plasma in the pediatric age group and in congenital coagulation factor deficiency. Thromb Res. 2002 Oct 31;107 Suppl 1:S29-32. [12379290]
  4. Perry DJ. Factor VII deficiency. Blood Coagul Fibrinolysis. 2003 Jun;14 Suppl 1:S47-54. [14567537]
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