Stephen J. Schueler, M.D.

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Factor 5 Deficiency Overview

What is factor 5 deficiency?
A person with factor 5 deficiency has a rare, hereditary blood clotting disorder that can result in severe bleeding. Normal blood coagulation requires the complex interaction of about 20 proteins, called clotting factors. Low levels of factor 5 result in prolonged blood clotting.

What are the symptoms of factor 5 deficiency?
Symptoms of factor 5 deficiency include bleeding into the joints, joint swelling, joint pain, bleeding gums, nosebleeds, and easy bruising. Women may experience heavy menstrual periods.

How does the doctor treat factor 5 deficiency?
There is no cure for factor 5 deficiency. Treatment for factor 5 deficiency may include, fresh frozen plasma and vitamin K. Patients should avoid aspirin, nonsteroidal anti-inflammatory medications, and other medications that can promote bleeding.

Continue to Factor 5 Deficiency Symptoms

Last Updated: Jan 11, 2011 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Factor 5 Deficiency References
  1. Garcia-Noblejas A, Osorio S, Duran AI, Cordoba R, Nistal S, Aguado B, Loscertales J, Gomez N. Pulmonary embolism in a patient with severe congenital deficiency for factor V during treatment with fresh frozen plasma. Haemophilia. 2005 May;11(3):276-9. [15876274]
  2. Lak M, Sharifian R, Peyvandi F, Mannucci PM. Symptoms of inherited factor V deficiency in 35 Iranian patients. Br J Haematol. 1998 Dec;103(4):1067-9. [9886321]
  3. Muntean W. Fresh frozen plasma in the pediatric age group and in congenital coagulation factor deficiency. Thromb Res. 2002 Oct 31;107 Suppl 1:S29-32. [12379290]
  4. Sirachainan N, Zhang B, Chuansumrit A, Pipe S, Sasanakul W, Ginsburg D. Combined factor V and factor VIII deficiency in a Thai patient: a case report of genotype and phenotype characteristics. Haemophilia. 2005 May;11(3):280-4. [15876275]
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