Factor 12 Deficiency Underlying Cause
Normal blood clotting requires the complex interaction of about 20 different blood proteins. Many of these proteins are manufactured in the liver and are regulated by the activities of enzymes and other cofactors.
Factor 12 deficiency is an inherited illness. Low levels of this clotting factor do not result in prolonged blood clotting.
- Baker WF Jr, Bick RL. Treatment of hereditary and acquired thrombophilic disorders. Semin Thromb Hemost. 1999;25(4):387-406. 
- Girolami A, Simioni P, Scarano L, Girolami B, Zerbinati P. Symptomatic combined homozygous factor XII deficiency and heterozygous factor V Leiden. J Thromb Thrombolysis. 2000 Apr;9(3):271-5. 
- Muntean W. Fresh frozen plasma in the pediatric age group and in congenital coagulation factor deficiency. Thromb Res. 2002 Oct 31;107 Suppl 1:S29-32.