Stephen J. Schueler, M.D.

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Factor 12 Deficiency Overview

What is factor 12 deficiency?
A person with factor 12 deficiency has a rare, hereditary condition that results in low levels of a protein involved in blood clotting. However, the person's blood clots normally. Normal blood coagulation requires the complex interaction of about 20 proteins, called clotting factors.

What are the symptoms of factor 12 deficiency?
There are usually no symptoms of factor 12 deficiency.

How does the doctor treat factor 12 deficiency?
Patients with factor 12 deficiency should avoid aspirin, nonsteroidal anti-inflammatory medications, and other medications that can promote bleeding.

Continue to Factor 12 Deficiency Symptoms

Last Updated: Feb 8, 2010 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Factor 12 Deficiency References
  1. Baker WF Jr, Bick RL. Treatment of hereditary and acquired thrombophilic disorders. Semin Thromb Hemost. 1999;25(4):387-406. [10548072]
  2. Girolami A, Simioni P, Scarano L, Girolami B, Zerbinati P. Symptomatic combined homozygous factor XII deficiency and heterozygous factor V Leiden. J Thromb Thrombolysis. 2000 Apr;9(3):271-5. [10728027]
  3. Muntean W. Fresh frozen plasma in the pediatric age group and in congenital coagulation factor deficiency. Thromb Res. 2002 Oct 31;107 Suppl 1:S29-32. [12379290]
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