Stephen J. Schueler, M.D.

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Factor 10 Deficiency Overview

What is factor 10 deficiency?
A person with factor 10 deficiency has a rare, hereditary blood clotting disorder that can result in severe bleeding. Normal blood coagulation requires the complex interaction of about 20 proteins, called clotting factors. Low levels of factor 10 result in prolonged blood clotting.

What are the symptoms of factor 10 deficiency?
Symptoms of a factor 10 deficiency include bleeding into the joints, joint swelling, joint pain, bleeding gums, nosebleeds, and easy bruising. Women may experience heavy menstrual periods.

How does the doctor treat factor 10 deficiency?
There is no cure for factor 10 deficiency. Treatment for factor 10 deficiency may include fresh frozen plasma, factor X concentrate, and vitamin K. Patients should avoid aspirin, nonsteroidal anti-inflammatory medications, and other medications that can promote bleeding.

Continue to Factor 10 Deficiency Symptoms

Last Updated: Feb 8, 2010 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Factor 10 Deficiency References
  1. Baker WF Jr, Bick RL. Treatment of hereditary and acquired thrombophilic disorders. Semin Thromb Hemost. 1999;25(4):387-406. [10548072]
  2. McMahon C, Smith J, Goonan C, Byrne M, Smith OP. The role of primary prophylactic factor replacement therapy in children with severe factor X deficiency. Br J Haematol. 2002 Dec;119(3):789-91. [12437661]
  3. Muntean W. Fresh frozen plasma in the pediatric age group and in congenital coagulation factor deficiency. Thromb Res. 2002 Oct 31;107 Suppl 1:S29-32. [12379290]
  4. Uprichard J, Perry DJ. Factor X deficiency. Blood Rev. 2002 Jun;16(2):97-110. [12127953]
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