The evaluation of erythroblastosis fetalis begins with a history and physical examination.

Physical findings in infants with erythroblastosis fetalis may include:

• Jaundice:
• Yellow skin
• Yellow eyes
• Brown urine
• Lethargy:
• A condition of excessive sleepiness or drowsiness.
• Poor feeding in infants
• Enlargement of the liver
• Enlargement of the spleen

Tests that may be used to evaluate erythroblastosis fetalis include:

• Coagulation profile
• Complete blood count
• Direct bilirubin
• Indirect bilirubin
• Liver profile
• Reticulocyte count
• Total bilirubin
• Coomb's testing:
• This condition will cause a positive indirect Coombs test in the mother and a positive direct Coombs test in the fetus. These tests show the mother's blood has antibodies to Rh factor, and the fetal blood cells have antibodies attached to them.

Imaging tests that may be used to evaluate erythroblastosis fetalis include:

• Ultrasound of the abdomen