Duodenal Ulcer Treatment
Treatment for peptic ulcer disease usually includes antacids, antibiotics, and medications that block the production of stomach acid. Rarely, severe peptic ulcer disease may require surgery.
In most cases, PUD can be successfully treated over 2 weeks using triple therapy:
Treatment options for peptic ulcer disease include:
- Avoidance of nonsteroidal anti-inflammatory medications
- Stomach acid-blocker medications:
- Proton pump inhibitor medications:
- Omeprazole (Prilosec)
- Pantoprazole (Protonix)
- Esomeprazole (Nexium)
- Lansoprazole (Prevacid)
- Rabeprazole (Aciphex)
- Antibiotics for peptic ulcer disease:
- Bismuth subsalicylate
- Surgery for peptic ulcer disease
For more information:
Duodenal Ulcer Drugs
Treatment for peptic ulcer disease usually requires killing the Helicobacter pylori bacteria in the stomach. This is accomplished by taking a combination of antibiotics and acid-blocking drugs. The antibiotics must be taken for 14 days. The acid-blocking medication is usually taken for at least 4 weeks. Your doctor will determine which of the following combinations is best for you.
One of the following antibiotic combination options:
- 14 days of clarithromycin (Biaxin) and amoxicillin (Amoxil, Trimox)
- 14 days of metronidazole (Flagyl) and amoxicillin (Amoxil, Trimox)
- 14 days of metronidazole (Flagyl) and tetracycline (Sumycin)
One of the following acid-blocking medication options:
- Proton pump inhibitor medications:
The most commonly prescribed combination of medication used to treat peptic ulcer disease includes:
If one of the above treatment combinations fails, quadruple drug therapy may be used to treat peptic ulcer disease:
Duodenal Ulcer Questions For Doctor
The following are some important questions to ask before and after the treatment of peptic ulcer disease.
Questions to ask before treatment:
- What are my treatment options?
- Is surgery an option for me?
- What are the risks associated with treatment?
- Do I need to stay in the hospital?
- How long will I be in the hospital?
- What are the complications I should watch for?
- How long will I be on medication?
- What are the potential side effects of my medication?
- Does my medication interact with nonprescription medicines or supplements?
- Should I take my medication with food?
Questions to ask after treatment:
- Do I need to change my diet?
- Do I need to lose weight?
- Are there any medications or supplements I should avoid?
- When can I resume my normal activities?
- When can I return to work?
- What else can I do to reduce my risk for peptic ulcer disease complications?
- How often will I need to see my doctor for checkups?
- What local support and other resources are available?
Duodenal Ulcer Specialist
Physicians from the following specialties evaluate and treat peptic ulcer disease:
Duodenal Ulcer Surgery
Surgery may be required for peptic ulcer disease in the following cases:
- The ulcer forms a hole through the wall of the stomach or intestine
- The ulcer causes bleeding
- The ulcer obstructs the movement of food through the intestine
Surgery for peptic ulcer disease includes:
- Removal of a portion of the stomach
- Cutting the nerves that supply the stomach
- Surgery on the lower portion of the stomach, near the first part of the small intestine
- Generally combined with vagotomy
Continue to Duodenal Ulcer Home Care
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- Ford A, Delaney B, Forman D, Moayyedi P. Eradication therapy for peptic ulcer disease in Helicobacter pylori positive patients. Cochrane Database Syst Rev. 2004 Oct 18;(4):CD003840. 
- Ford AC, Delaney BC, Forman D, Moayyedi P. Eradication therapy in Helicobacter pylori positive peptic ulcer disease: systematic review and economic analysis. Am J Gastroenterol. 2004 Sep;99(9):1833-55. 
- Vakil N, Fennerty MB. Direct comparative trials of the efficacy of proton pump inhibitors in the management of gastro-oesophageal reflux disease and peptic ulcer disease. Aliment Pharmacol Ther. 2003 Sep 15;18(6):559-68.