The following lists of digestive diseases are organized by how common they are, and whether they are acute (short-lived) or chronic (longstanding) illnesses.

Common causes for acute digestive disease include:

• Acute gastritis
• Anxiety
• Bacterial gastroenteritis:
• Salmonella infection
• Shigella gastroenteritis
• E. coli gastroenteritis
• Campylobacter enteritis
• Drug side effect
• Incarcerated hernia
• Food poisoning
• Traveler's diarrhea
• Hepatitis A
• Mesenteric lymphadenitis
• Viral gastroenteritis:
• Rotavirus infection
• Norwalk virus infection

Common causes for chronic digestive disease include:

• Alcoholic hepatitis
• Anxiety disorder
• Chronic gastritis
• Colon polyps
• Depression
• Diabetes
• Food allergies
• Food intolerance
• Hiatal hernia
• Irritable bowel syndrome
• Lactose intolerance
• Parasites:
• Ciguatera poisoning
• Cryptosporidium enterocolitis
• Entamoeba infection
• Giardiasis
• Pinworms
• Trichinosis
• Peptic ulcer disease
• Reflux esophagitis

Less common causes for acute digestive disease include:

• Acute cholecystitis
• Acute pancreatitis
• Angiodysplasia
• Appendicitis
• Botulism
• Cholangitis
• Diverticulitis
• Gallstones
• Hepatitis B
• Hepatitis C
• Intestinal obstruction
• Intussusception
• Perianal abscess
• Proctitis
• Pseudomembranous colitis
• Toxic megacolon
• Incarcerated umbilical hernia

Less common causes for chronic digestive disease include:

• Achalasia
• Addison's disease
• Carcinoid syndrome
• Celiac sprue
• Cirrhosis
• Colon cancer
• Crohn's disease
• Dumping syndrome
• Esophageal cancer
• Esophageal spasm
• Familial Mediterranean fever
• Gallbladder cancer
• Gastric cancer
• Hirschsprung's disease
• Hyperthyroidism
• Ischemic colitis
• Liver cancer
• Pancreatic cancer
• Pernicious anemia
• Primary biliary cirrhosis
• Sickle cell anemia
• Tropical sprue
• Ulcerative colitis
• Zollinger-Ellison syndrome