Stephen J. Schueler, M.D.

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Cushing's Disease Overview

What is Cushing's disease?
A person with Cushing's disease has symptoms caused by an excess of the adrenal hormone, cortisol, which regulates metabolism. The most common cause for Cushing's disease is a pituitary tumor. The pituitary tumor stimulates the adrenal glands to produce too much cortisol. Less common causes for Cushing's disease include small cell carcinoma of the lung and bronchial carcinoid tumor.

What are the symptoms of Cushing's disease?
Symptoms of Cushing's disease include absent menstrual periods, delayed wound healing, emotional instability, swelling, high blood pressure, hyperglycemia, hirsutism, kidney stones, muscle wasting, muscle weakness, osteoporosis, stretch marks, obesity, and thinning of skin.

How does the doctor treat Cushing's disease?
Treatment of Cushing's disease may include surgery to remove a pituitary tumor and medications to control hormone levels.

Continue to Cushing's Disease Incidence

Last Updated: Aug 25, 2010 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Cushing's Disease References
  1. Burch WM. Cushing's disease. A review. Arch Intern Med. 1985 Jun;145(6):1106-11. [3923962]
  2. Heaney AP. Novel medical approaches for the treatment of Cushing's disease. J Endocrinol Invest. 2004 Jun;27(6):591-5. [15717660]
  3. Mahmoud-Ahmed AS, Suh JH. Radiation therapy for Cushing's disease: a review. Pituitary. 2002;5(3):175-80. [12812309]
  4. Medical therapy of Cushing's disease. Pituitary. 2002;5(2):77-82. [12675504]
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