The evaluation of cryptosporidium enterocolitis begins with a medical history and physical examination.

Physical findings of cryptosporidium enterocolitis may include:

• Fever
• Signs of dehydration
• Signs of dehydration include:
• Pale, dry skin
• Dry eyes and mouth
• Sunken eyes
• Sunken fontanelle in infants
• Rapid pulse
• Low blood pressure when standing
• Orthostatic hypotension
• Confusion
• With severe dehydration
• Lethargy:
• A condition of excessive sleepiness or drowsiness.
• With severe dehydration

The diagnosis of cryptosporidium enteritis must be confirmed through testing. A stool examination for ova and parasites can be helpful in detecting the infection.

A stool culture can detect:

• Shigella infection
• Campylobacter enteritis
• Cryptosporidium enterocolitis
• Giardiasis
• Pseudomembranous colitis:
• Clostridium difficile
• Salmonella gastroenteritis
• Traveler's diarrhea due to bacterial infection
• E. coli

Tests that may be used to evaluate cryptosporidium enterocolitis include:

• Complete blood count
• Liver profile
• Kidney profile