The symptoms of cryptococcal infection depend on the location of the infection.

Symptoms of cryptococcal infection of the lung include:

• Chest pain
• Cough
• Anorexia

Symptoms of cryptococcal meningitis or encephalitis include:

• Blurred vision
• Confusion
• Headache
• Irritability
• Nausea
• Staggering gait

Skin lesions are present in less than 10% of patients with cryptococcal infection. The presence of skin lesions generally indicates a widespread infection.