Creutzfeldt-Jakob Disease Underlying Cause
Prion proteins occur in both a normal form, which is a harmless protein found in the body's cells, and in an infectious form, which causes disease. The infectious form of the protein has a different folded shape than the normal form. Once the abnormal prions appear, they clump together within cells and somehow trigger cell death.
There are three major categories of CJD:
Continue to Creutzfeldt-Jakob Disease Transmission
- Beghi E, Gandolfo C, Ferrarese C, Rizzuto N, Poli G, Tonini MC, Vita G, Leone M, Logroscino G, Granieri E, Salemi G, Savettieri G, Frattola L, Ru G, Mancardi GL, Messina C. Bovine spongiform encephalopathy and Creutzfeldt-Jakob disease: facts and uncertainties underlying the causal link between animal and human diseases. Neurol Sci. 2004 Jul;25(3):122-9. 
- Glatzel M, Stoeck K, Seeger H, Luhrs T, Aguzzi A. Human prion diseases: molecular and clinical aspects. Arch Neurol. 2005 Apr;62(4):545-52. 
- Mallucci G, Collinge J. Update on Creutzfeldt-Jakob disease. Curr Opin Neurol. 2004 Dec;17(6):641-7.