Coronary Syndrome Underlying Cause
Acute coronary syndrome is caused by narrowing of a coronary artery. The coronary arteries become narrowed by a process known as atherosclerosis, which is also called hardening of the arteries. Narrowed coronary arteries may not supply enough oxygen to meet the demands of the heart muscle. Symptoms of acute coronary syndrome occur during activities that increase the activity of the heart.
The process of atherosclerosis includes:
- The inner wall of the artery becomes damaged by:
- As the wall or the artery attempts to repair itself, cholesterol builds up on the inside surface of the artery, forming a plaque.
- Plaques narrow the inside of the arteries, which reduces blood flow. This can lead to blood clot formation inside the vessel.
Continue to Coronary Syndrome Anatomy
- Achar SA, Kundu S, Norcross WA. Diagnosis of acute coronary syndrome. Am Fam Physician. 2005 Jul 1;72(1):119-26. 
- Brown TL, Merrill J, Hill P, Bengel FM. Relationship of coronary calcium and myocardial perfusion in individuals with chest pain. Assessed by integrated rubidium-82 PET-CT. Nuklearmedizin. 2008;47(6):255-260. 
- Mattu A, Petrini J, Swencki S, Chaudhari C, Brady WJ. Premature atherosclerosis and acute coronary syndrome in systemic lupus erythematosus. Am J Emerg Med. 2005 Sep;23(5):696-703. 
- Moriel M, Behar S, Tzivoni D, Hod H, Boyko V, Gottlieb S. Management and outcomes of elderly women and men with acute coronary syndromes in 2000 and 2002. Arch Intern Med. 2005 Jul 11;165(13):1521-6. 
- Ofili E. Acute coronary syndrome in women. J Fam Pract. 2005 Jul;Suppl:6-7. 
- Perers E, Caidahl K, Herlitz J, Karlson BW, Karlsson T, Hartford M. Treatment and short-term outcome in women and men with acute coronary syndromes. Int J Cardiol. 2005 Aug 18;103(2):120-7. 
- Thuresson M, Jarlov MB, Lindahl B, Svensson L, Zedigh C, Herlitz J. Symptoms and type of symptom onset in acute coronary syndrome in relation to ST elevation, sex, age, and a history of diabetes. Am Heart J. 2005 Aug;150(2):234-42. 
- Wallentin L. Prevention of cardiovascular events after acute coronary syndrome. Semin Vasc Med. 2005 Aug;5(3):293-300. 
- Yilmaz H, Basarici I. Troponin levels and acute coronary syndrome. J Am Coll Cardiol. 2005 Aug 16;46(4):741.