Mild cases do not require treatment. Most cases of coccidioidomycosis resolve on their own.

Treatment for severe cases of coccidioidomycosis may include:

• Anti-fungal medications for coccidioidomycosis:
• Amphotericin B
• Ketoconazole
• Fluconazole
• Itraconazole
• Cold medications
• Decongestants
• Antihistamines
• Nonsteroidal anti-inflammatory medications for pain and fever
• Cough suppressants
• Coccidioidomycosis clinical trials