Stephen J. Schueler, M.D.

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CML Underlying Cause

The cause of chronic myelogenous leukemia is unknown, but genetics may play a role.

Genes control the functions inside a cell. Special genes control how cells divide and grow. Cancer occurs when the damaged genes stimulate the cell to multiply out of control. The exact cause for this damage is unknown.


  • DNA
  • Genes on chromosomes
  • Cancer cells
  • Cancer cell division

Continue to CML Anatomy

Last Updated: Dec 7, 2010 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed CML References
  1. O'Brien S, Tefferi A, Valent P. Chronic myelogenous leukemia and myeloproliferative disease. Hematology (Am Soc Hematol Educ Program). 2004;:146-62. [15561681]
  2. Randolph TR. Chronic myelocytic leukemia--Part I: History, clinical presentation, and molecular biology. Clin Lab Sci. 2005 Winter;18(1):38-48. [15747785]
  3. Van Etten RA, Shannon KM. Focus on myeloproliferative diseases and myelodysplastic syndromes. Cancer Cell. 2004 Dec;6(6):547-52. [15607959]
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