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- Rashes that look like broken blood vessels in the skin or bruises
- Liver enlargement
- Lymph node swelling
- Pale skin and eyes, along with other signs of anemia
- Skin infections
- Spleen enlargement
- Weight loss
- Abnormalities on examination of the retina
Testing is always needed to diagnose and monitor the status of chronic myelogenous leukemia.
Tests that may be used to evaluate chronic myelogenous leukemia may include:
- Coagulation profile
- Complete blood count
- Peripheral blood smear
- Usually shows abnormally high numbers of lymphocytes. The lymphocytes will also have an abnormal shape, size or character when viewed under a microscope.
- Bone marrow aspiration and biopsy
- Philadelphia chromosome analysis
- Detects abnormal DNA that may be present in leukemia
- A type of karyotype that is used to identify a chromosomal abnormality that is often associated with chronic myelogenous leukemia or CML. The analysis specifically looks for an exchange (translocation) of genetic material between chromosomes 9 and 22.
- Determines the type of abnormal lymphocyte
- Cytogenic analysis
- Detects DNA abnormalities in lymphocytes
- Detects CD5 and CD23 positive B cells
- Chest x-ray
Imaging tests for chronic myelogenous leukemia may include:
Continue to CML Treatment
PubMed CML References
- O'Brien S, Tefferi A, Valent P. Chronic myelogenous leukemia and myeloproliferative disease. Hematology (Am Soc Hematol Educ Program). 2004;:146-62. 
- Randolph TR. Chronic myelocytic leukemia--Part I: History, clinical presentation, and molecular biology. Clin Lab Sci. 2005 Winter;18(1):38-48. 
- Van Etten RA, Shannon KM. Focus on myeloproliferative diseases and myelodysplastic syndromes. Cancer Cell. 2004 Dec;6(6):547-52.