Stephen J. Schueler, M.D.

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Chronic Myelogenous Leukemia Evaluation

The evaluation of chronic myelogenous leukemia begins with a medical history and physical examination.

Physical findings in someone with chronic myelogenous leukemia may include:

Testing is always needed to diagnose and monitor the status of chronic myelogenous leukemia.

Tests that may be used to evaluate chronic myelogenous leukemia may include:
  • Coagulation profile
  • Complete blood count
  • Peripheral blood smear
    • Usually shows abnormally high numbers of lymphocytes. The lymphocytes will also have an abnormal shape, size or character when viewed under a microscope.
  • Bone marrow aspiration and biopsy
  • Philadelphia chromosome analysis
    • Detects abnormal DNA that may be present in leukemia
    • A type of karyotype that is used to identify a chromosomal abnormality that is often associated with chronic myelogenous leukemia or CML. The analysis specifically looks for an exchange (translocation) of genetic material between chromosomes 9 and 22.
  • Immunophenotyping
    • Determines the type of abnormal lymphocyte
  • Cytogenic analysis
    • Detects DNA abnormalities in lymphocytes
  • Immunophenotype:
    • Detects CD5 and CD23 positive B cells
  • Chest x-ray
  • Urinalysis

Imaging tests for chronic myelogenous leukemia may include:

Continue to Chronic Myelogenous Leukemia Treatment

Last Updated: Dec 9, 2010 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Chronic Myelogenous Leukemia References
  1. O'Brien S, Tefferi A, Valent P. Chronic myelogenous leukemia and myeloproliferative disease. Hematology (Am Soc Hematol Educ Program). 2004;:146-62. [15561681]
  2. Randolph TR. Chronic myelocytic leukemia--Part I: History, clinical presentation, and molecular biology. Clin Lab Sci. 2005 Winter;18(1):38-48. [15747785]
  3. Van Etten RA, Shannon KM. Focus on myeloproliferative diseases and myelodysplastic syndromes. Cancer Cell. 2004 Dec;6(6):547-52. [15607959]
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