Stephen J. Schueler, M.D.

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Christmas Disease Overview

Another name for Christmas Disease is Hemophilia B.

What is hemophilia B?
Hemophilia B is an inherited bleeding disorder that primarily affects males. A person with hemophilia B is missing a protein called factor 9, which helps form blood clots. Normal blood coagulation requires the complex interaction of about 20 proteins, called clotting factors. Low levels of factor 8 result in prolonged blood clotting.

What are the symptoms of hemophilia B?
Symptoms of hemophilia B include prolonged bleeding, bleeding into the joints, joint swelling, joint pains, knee pain, bleeding gums, fatigue, nose bleeding, excessive bruising, blood in the stool, black stool, and a rash that looks like bruises or broken blood vessels.

How does the doctor treat hemophilia B?
Treatment for hemophilia B includes intravenous infusions of factor 9, fresh frozen plasma, epsilon aminocaproic acid, and gene therapy.

Continue to Christmas Disease Risk Factors

Last Updated: Sep 4, 2010 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Christmas Disease References
  1. Dunn AL, Abshire TC. Recent advances in the management of the child who has hemophilia. Hematol Oncol Clin North Am. 2004 Dec;18(6):1249-76, viii. [15511615]
  2. Ettingshausen CE, Kreuz W. Long-term aspects of hemophilia B treatment: part I-role for prophylaxis. Blood Coagul Fibrinolysis. 2004 Jun;15 Suppl 2:S11-3. [15322452]
  3. Gringeri A. Long-term aspects of hemophilia B treatment: part II. Blood Coagul Fibrinolysis. 2004 Jun;15 Suppl 2:S15-6. [15322453]
  4. Leissinger CA. Prevention of bleeds in hemophilia patients with inhibitors: emerging data and clinical direction. Am J Hematol. 2004 Oct;77(2):187-93. [15389908]
  5. Plug I, van der Bom JG, Peters M, et al. Thirty years of hemophilia treatment in the Netherlands, 1972-2001. Blood. 2004 Dec 1;104(12):3494-500. [15308570]
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