Cancer Squamous Cell Anatomy
To better understand squamous cell carcinoma , it helps to understand the anatomy of the skin.
The skin contains three main layers:
- The superficial layer that makes up the surface of the skin
- It is composed of skin cells and can be divided into 5 layers based on cell type.
- The top layer of the epidermis, the stratum corneum, is made of dead, flat skin cells that shed about every 2 weeks.
- The thickness of the epidermis varies, according to location: it is very thick over the soles of the feet, and very thin over the ears.
- Lies beneath the epidermis
- Also varies in thickness depending on the location of the skin. It is .3 mm on the eyelid and 3.0 mm on the back.
- The dermis is composed of 2 layers that contain a connective tissue called collagen
- The dermis contains blood vessels, nerves, sweat glands, and hair follicles.
- The number of structures in the dermis varies, according to location.
- The dermis under the arms contains more sweat glands and hair follicles than the dermis on the back.
- Subcutaneous layer:
- Mainly fat and connective tissue.
- Contains blood vessels and nerves.
- Campbell FA, Gupta G. The management of non-melanoma skin cancer. Hosp Med. 2005 May;66(5):288-93. 
- Clayman GL, Lee JJ, Holsinger FC, et al. Mortality risk from squamous cell skin cancer. J Clin Oncol. 2005 Feb 1;23(4):759-65. 
- Einspahr JG, Bowden GT, Alberts DS. Skin cancer chemoprevention: strategies to save our skin. Recent Results Cancer Res. 2003;163:151-64; discussion 264-6. 
- Glass AG, Hoover RN. The emerging epidemic of melanoma and squamous cell skin cancer. JAMA. 1989 Oct 20;262(15):2097-100. 
- Yuspa SH. The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis. J Dermatol Sci. 1998 May;17(1):1-7.