Stephen J. Schueler, M.D.

Cancer Breast BRCA Markers


  • There are a number of genetic markers that appear to increase a woman's risk of breast cancer. The most important markers are called BRCA1 and BRCA2.
  • BRCA1 and BRCA2 are gene mutations often referred to as breast cancer susceptibility genes.
  • When BRCA1 and BRCA2 are positive in the setting of a strong family history of breast cancer, these genes can significantly increase a woman's risk.
  • The risk of breast cancer in women with these genetic abnormalities ranges from 50-85%.
  • Younger women, who have breast cancer and also have a family history of breast or ovarian cancer, are more likely to have BRCA1 or BRCA2 gene mutations.
  • Overall, about 5% to 10% of all cases of breast cancer are thought to be due to an inherited susceptibility to cancer, such as a mutation in BRCA1.

Continue to Cancer Breast Symptoms

Last Updated: Jun 2, 2009 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
Copyright DSHI Systems, Inc. Powered by: FreeMD - Your Virtual Doctor

PubMed Cancer Breast References
  1. Aiello EJ, Buist DS, White E, Seger D, Taplin SH. Rate of breast cancer diagnoses among postmenopausal women with self-reported breast symptoms. J Am Board Fam Pract. 2004 Nov-Dec;17(6):408-15. [15575032]
  2. Collaborative Group on Hormonal Factors in Breast Cancer: Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer. Collaborative Group on Hormonal Factors in Breast Cancer. Lancet 1997 Oct 11; 350(9084): 1047-59. [10213546]
  3. Giordano SH. A review of the diagnosis and management of male breast cancer. Oncologist. 2005 Aug;10(7):471-9. [16079314]
FreeMD is provided for information purposes only and should not be used as a substitute for evaluation and treatment by a physician. Please review our terms of use.