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BRCA markers
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Facts: - There are a number of genetic markers that appear to increase a woman's risk of breast cancer. The most important markers are called BRCA1 and BRCA2.
- BRCA1 and BRCA2 are gene mutations often referred to as breast cancer susceptibility genes.
- When BRCA1 and BRCA2 are positive in the setting of a strong family history of breast cancer, these genes can significantly increase a woman's risk.
- The risk of breast cancer in women with these genetic abnormalities ranges from 50-85%.
- Younger women, who have breast cancer and also have a family history of breast or ovarian cancer, are more likely to have BRCA1 or BRCA2 gene mutations.
- Overall, about 5% to 10% of all cases of breast cancer are thought to be due to an inherited susceptibility to cancer, such as a mutation in BRCA1.
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