The evaluation of blastomycosis begins with a medical history and physical examination.

Skin lesions may be the only physical finding of blastomycosis. The skin lesions may be skin lumps, skin bumps, or skin ulcers.

The diagnosis of blastomycosis must be confirmed through testing.

Tests that may be used to evaluate blastomycosis include:

• Chest x-ray
• Sputum culture
• Chest CT scanning
• CT scanning of the brain
• MRI scan of the brain

Less common tests that may be used to evaluate blastomycosis include:

• Bronchoscopy:
• To obtain sputum for bacterial cultures and fungal studies.