Stephen J. Schueler, M.D.

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Bile Duct Cancer Underlying Cause

The cause of cholangiocarcinoma is unknown, but genetics may play a role. Gallstones, chronic viral hepatitis, and cirrhosis do not appear to be factors in the development of cholangiocarcinoma.

Genes control the functions inside a cell. Special genes control how cells divide and grow. Cancer occurs when the damaged genes stimulate the cell to multiply out of control. The exact cause for this damage is unknown.


  • DNA
  • Genes on chromosomes
  • Cancer cells
  • Cancer cell division

Continue to Bile Duct Cancer Anatomy

Last Updated: Jun 24, 2008 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Bile Duct Cancer References
  1. Jones BA, Gores GJ. Hepatobiliary malignancy. Clin Liver Dis. 1998 May;2(2):437-49, xi-xii. [15560042]
  2. Lazaridis KN, Gores GJ. Cholangiocarcinoma. Gastroenterology. 2005 May;128(6):1655-67. [15887157]
  3. Thongprasert S. The role of chemotherapy in cholangiocarcinoma. Ann Oncol. 2005;16 Suppl 2:ii93-6. [15958484]
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