Stephen J. Schueler, M.D.

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Antiphospholipid Syndrome Overview

Another name for Antiphospholipid Syndrome is Antiphospholipid Antibody Syndrome.

What is antiphospholipid antibody syndrome?
A person with antiphospholipid antibody syndrome has an abnormal immune system that mistakenly attacks phospholipids, which are an important part of cell membranes. The immune system makes antibodies that bind to phospholipids, it causes the blood to form clots. Antiphospholipid antibody syndrome may be seen in association with deep venous thrombosis, stroke, heart attack, and pregnancy.

What are the symptoms of antiphospholipid antibody syndrome?
People with antiphospholipid antibody syndrome will often form blood clots in the legs, a condition known as deep venous thrombosis. This causes leg pain and leg swelling.

How does the doctor treat antiphospholipid antibody syndrome?
Antiphospholipid antibody syndrome is treated with anticoagulants such as heparin and Coumadin.

Continue to Antiphospholipid Syndrome Risk Factors

Last Updated: Mar 5, 2010 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Antiphospholipid Syndrome References
  1. Garcia DA, Khamashta MA, Crowther MA. How we diagnose and treat thrombotic manifestations of the antiphospholipid syndrome: a case-based review. Blood. 2007 Nov 1;110(9):3122-7. Epub 2007 Jul 20. [17644740]
  2. Musuruana JL, Cavallasca JA. Polyarteritis nodosa complicated by antiphospholipid syndrome. South Med J. 2008 Apr;101(4):419-21. [18360325]
  3. Uthman I, Khamashta M. The abdominal manifestations of the antiphospholipid syndrome. Rheumatology (Oxford). 2007 Nov;46(11):1641-7. Epub 2007 Jul 17. [17636180]
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