The following drugs are used in the treatment of ankylosing spondylitis.

Nonsteroidal anti-inflammatory drugs
These medications relieve pain and reduce inflammation. Examples include:

• Ibuprofen
• Naproxen
• Ketoprofen

Immunomodulatory agents
Etanercept is a monoclonal antibody that exerts its effect by binding to a compound known as tumor necrosis factor. Once bound by the antibody tumor necrosis factor cannot function. Tumor necrosis factor is a chemical that is involved in normal inflammatory and immune responses. Another option in this class is infliximab (Remicade).

Disease-modifying antirheumatic drugs
Also referred to as DMARDs these medications help to reduce inflammation. Examples include sulfasalazine (Azulfidine) and methotrexate (Rheumatrex).

Corticosteroids
Steroid medications, such as prednisone, can suppress inflammation and slow damage to joints. Although most commonly taken as pills, severe episodes of inflammation or persistent pain may require treatment with injections.