Stephen J. Schueler, M.D.

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Anaphylactic Reaction Antihistamines

Antihistamines, such as diphenhydramine (Benadryl) and cimetidine help block the actions of histamine, which causes symptoms of anaphylaxis.

Diphenhydramine Dosing Chart

AgeDoseIntervalMax Daily Dose
2-5 years6.25 mg4-6 hours37.5 mg/day
6-11 years12.5-25 mg4-6 hours150 mg/day
12 and older25-50 mg4-6 hours300 mg/day

Continue to Anaphylactic Reaction Corticosteroids

Last Updated: Nov 8, 2010 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Anaphylactic Reaction References
  1. Atkinson TP, Kaliner MA: Anaphylaxis. Med Clin North Am 1992 Jul; 76(4): 841-55. [1614236]
  2. Busse WW: Mechanisms and advances in allergic diseases. J Allergy Clin Immunol 2000 Jun; 105(6 Pt 2): S593-8. [10856163]
  3. Nimmagadda SR, Evans R 3rd: Allergy: etiology and epidemiology. Pediatr Rev 1999 Apr; 20(4): 111-5. [10208083]
  4. Reisman RE: Insect stings. N Engl J Med 1994 Aug 25; 331(8): 523-7. [8041420]
  5. Sheikh A, Walker S. Anaphylaxis. BMJ. 2005 Aug 6;331(7512):330. [16081446]
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