The evaluation of an amyloidosis begins with a medical history and physical examination.

Physical findings in those with amyloidosis may include:

• Enlargement of the liver
• Ascites
• Generalized lymph node swelling
• Skin lesions: waxy, translucent raised skin lesions may be seen on the face, around the eyes, or inside the mouth.

Tests are usually necessary to confirm the diagnosis of amyloidosis.

Blood tests for amyloidosis may include:

• Electrolyte profile
• Complete blood count
• Kidney profile:
• Abnormal in up to 80% of patients
• Angiotensin converting enzyme level:
• May be elevated

Other tests for amyloidosis may include:

• EKG
• Echocardiogram
• Bence Jones protein:
• May be positive in the urine
• Urinalysis:
• Will usually show elevated quantities of protein due to nephrotic syndrome
• Chest x-ray

A tissue biopsy is required to confirm the diagnosis of amyloidosis. This may be achieved using:

• Rectal biopsy
• Bone marrow biopsy
• Kidney biopsy
• Liver biopsy
• Abdominal fat pad biopsy