|
drugs
|
Medications used to treat Alzheimer's disease include: - Donepezil (Aricept)
- This drug is called a cholinesterase inhibitor because it blocks the breakdown of the neurotransmitter acetyl choline in the brain.
- Low levels of acetyl choline in some regions of the brain are thought to be responsible for some Alzheimer's symptoms.
- Donepezil is approved for use at all stages of the disease: mild, moderate, and severe
- May improve mental function (such as memory) in some patients. Will not work in roughly half of all users.
- Side effects include nausea, vomiting, diarrhea, fatigue, weight loss, and insomnia.
- Tacrine (Cognex)
- This drug is also a cholinesterase inhibitor because it blocks the breakdown of the neurotransmitter acetyl choline in the brain.
- May improve mental function (such as memory) in some patients.
- Side effects include nausea, vomiting, diarrhea, fatigue, rash, abdominal pain, and indigestion.
- Less commonly tacrine may cause liver damage so blood tests (liver profile) needs to be monitored when taking the drug.
- Memantine (Namenda)
- Works by affecting the metabolism of glutamate in the brain. Glutamate plays a role in memory and learning. In Alzheimer's there is too much glutamate and memantine helps regulate glutamate levels in the brain.
- Approved for use in moderate to severe Alzheimer's disease.
- May improve mental function (such as memory) in some patients.
- May work better when used in combination with other Alzheimer's drugs such as donepezil, tacrine, rivastigmine, or galantamine.
- Side effects include fatigue, confusion, dizziness, and headache.
- Galantamine (Razadyne)
- This drug is called a cholinesterase inhibitor because it blocks the breakdown of the neurotransmitter acetyl choline in the brain.
- Most effective when given at early stages of the disease.
- May improve mental function (such as memory) in some patients.
- Side effects include nausea, vomiting, diarrhea, fatigue, weight loss, and insomnia.
- Rare deaths have been reported from heart attack and stroke.
- Rivastigmine (Exelon)
- This drug is called a cholinesterase inhibitor because it blocks the breakdown of the neurotransmitter acetyl choline in the brain.
- Most effective when given at early stages of the disease.
- May improve mental function (such as memory) in some patients.
- Side effects include nausea, vomiting, diarrhea, fatigue, weight loss, and insomnia.
- Rare deaths have been reported from heart attack and stroke.
|
Related Topics:
|