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Alzheimer's Disease Treatment: Drugs
Medications used to treat Alzheimer's disease include:
  • Donepezil (Aricept)
    • This drug is called a cholinesterase inhibitor because it blocks the breakdown of the neurotransmitter acetyl choline in the brain.
    • Low levels of acetyl choline in some regions of the brain are thought to be responsible for some Alzheimer's symptoms.
    • Donepezil is approved for use at all stages of the disease: mild, moderate, and severe
    • May improve mental function (such as memory) in some patients. Will not work in roughly half of all users.
    • Side effects include nausea, vomiting, diarrhea, fatigue, weight loss, and insomnia.
  • Tacrine (Cognex)
    • This drug is also a cholinesterase inhibitor because it blocks the breakdown of the neurotransmitter acetyl choline in the brain.
    • May improve mental function (such as memory) in some patients.
    • Side effects include nausea, vomiting, diarrhea, fatigue, rash, abdominal pain, and indigestion.
    • Less commonly tacrine may cause liver damage so blood tests (liver profile) needs to be monitored when taking the drug.
  • Memantine (Namenda)
    • Works by affecting the metabolism of glutamate in the brain. Glutamate plays a role in memory and learning. In Alzheimer's there is too much glutamate and memantine helps regulate glutamate levels in the brain.
    • Approved for use in moderate to severe Alzheimer's disease.
    • May improve mental function (such as memory) in some patients.
    • May work better when used in combination with other Alzheimer's drugs such as donepezil, tacrine, rivastigmine, or galantamine.
    • Side effects include fatigue, confusion, dizziness, and headache.
  • Galantamine (Razadyne)
    • This drug is called a cholinesterase inhibitor because it blocks the breakdown of the neurotransmitter acetyl choline in the brain.
    • Most effective when given at early stages of the disease.
    • May improve mental function (such as memory) in some patients.
    • Side effects include nausea, vomiting, diarrhea, fatigue, weight loss, and insomnia.
    • Rare deaths have been reported from heart attack and stroke.
  • Rivastigmine (Exelon)
    • This drug is called a cholinesterase inhibitor because it blocks the breakdown of the neurotransmitter acetyl choline in the brain.
    • Most effective when given at early stages of the disease.
    • May improve mental function (such as memory) in some patients.
    • Side effects include nausea, vomiting, diarrhea, fatigue, weight loss, and insomnia.
    • Rare deaths have been reported from heart attack and stroke.
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Last Updated: Apr 14, 2008  References
Authors: Stephen J. Schueler, MDJohn H. Beckett, MDD. Scott Gettings, MD
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