Stephen J. Schueler, M.D.

Overview Incidence Symptoms Evaluation Treatment specialist Outlook Underlying Cause Types adult childhood infantile

Alkaline Phosphatase Decreased Types

Types of hypophosphatasia include:

  • Infantile hypophosphatasia:
    • The most common and severe form
  • Childhood hypophosphatasia:
    • A less severe form
  • Adult Hypophosphatasia:
    • Very rare form that is not detected until later in life

Alkaline Phosphatase Decreased Adult

Adult hypophosphatasia is very rare and shares many of the same features as childhood hypophosphatasia.

Symptoms of hypophosphatasia in adults include:

  • Premature loss of teeth
  • Loss of bone density
  • Bony deformities
  • Gout
  • Bone fractures

Alkaline Phosphatase Decreased Childhood

Symptoms of childhood hypophosphatasia start after 6 months of age.

Symptoms of hypophosphatasia in children include:

  • Retarded growth
  • Premature loss of primary teeth
  • Loss of bone density
  • Bony deformities
  • Dwarfism
  • Bone fractures

Alkaline Phosphatase Decreased Infantile

Infantile hypophosphatasia is the most common form of hypophosphatasia. Symptoms start before 6 months of age.

Symptoms of hypophosphatasia in infants include:


Less than 50% of infants survive the illness.

Last Updated: Dec 16, 2010 References
Authors: Stephen J. Schueler, MD; John H. Beckett, MD; D. Scott Gettings, MD
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PubMed Alkaline Phosphatase Decreased References
  1. Girschick HJ, Schneider P, Kruse K, Huppertz HI. Bone metabolism and bone mineral density in childhood hypophosphatasia. Bone. 1999 Sep;25(3):361-7. [10495141]
  2. Girschick HJ, Seyberth HW, Huppertz HI. Treatment of childhood hypophosphatasia with nonsteroidal antiinflammatory drugs. Bone. 1999 Nov;25(5):603-7. [10574582]
  3. Wendling D, Jeannin-Louys L, Kremer P, Fellmann F, Toussirot E, Mornet E. Adult hypophosphatasia. Current aspects. Joint Bone Spine. 2001 Mar;68(2):120-4. [11324927]
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