Adrenal Insufficiency Underlying Cause
There are two types of Addison's disease:
- Primary Addison's disease
- Secondary Addison's disease
In both cases, there is insufficient production of adrenal hormones.
Adrenal Insufficiency Primary Disease
In primary Addison's disease, the adrenal gland is damaged by the immune system, which normally fights infection. For some reason, the immune system mistakenly attacks the adrenal gland, damaging the cells, which reduces the production of adrenal hormones.
Adrenal Insufficiency Secondary Disease
Secondary Addison's disease is caused by the malfunction of pituitary gland, or hypothalamus, which normally stimulates the adrenal glands to produce hormones. If the pituitary gland does not stimulate the adrenal glands, then the adrenal glands do not produce hormones.
Continue to Adrenal Insufficiency Anatomy
- Baker JT. Adrenal disorders. A primary care approach. Lippincotts Prim Care Pract. 1997 Nov-Dec;1(5):527-36. 
- Don-Wauchope AC, Toft AD. Diagnosis and management of Addison's disease. Practitioner. 2000 Sep;244(1614):794-9. 
- Lin L, Achermann JC. The adrenal. Horm Res. 2004;62 Suppl 3:22-9. 
- Marzotti S, Falorni A. Addison's disease. Autoimmunity. 2004 Jun;37(4):333-6. 
- Perry CG, Connell JM. Key developments in endocrinology. Practitioner. 2003 Jul;247(1648):555, 558, 562.