Adrenal Hyperplasia Underlying Cause
Congenital adrenal hyperplasia causes a deficiency in the hormones cortisol and aldosterone. This is because a defective gene cannot make an enzyme required by the adrenal gland to produce cortisol. Since the adrenals cannot make cortisol, the pituitary gland continues to stimulate them by producing high levels of the hormone ACTH. The stimulated adrenals enlarge and produce excessive levels of chemicals that have the same effect as male sex hormones.
The adrenal glands are normally regulated by the pituitary gland.
Continue to Adrenal Hyperplasia Anatomy
- Creighton S. Early versus late intervention of congenital adrenal hyperplasia. J Pediatr Adolesc Gynecol. 2004 Dec;17(6):411. 
- Merke DP, Bornstein SR. Congenital adrenal hyperplasia. Lancet. 2005 Jun 18-24;365(9477):2125-36.