The evaluation of acute intermittent porphyria begins with a medical history and physical examination.

The physical examination is usually normal.

Physical findings in those with acute intermittent porphyria may include:

• Peripheral neuropathy
• Decreased deep tendon reflexes
• Rapid pulse
• Hypertension
• Fever

Tests are required to make the diagnosis of acute intermittent porphyria.

Tests for acute intermittent porphyria may include:

• Complete blood count
• Kidney profile
• Urinalysis
• Blood porphyrins
• Urine porphobilinogens
• Urine porphyrins
• Blood assays for enzymes involved in heme metabolism