The evaluation of acrodermatitis enteropathica begins with a history and physical examination.

Physical findings in someone with acrodermatitis enteropathica include:

• Rash
• Nail abnormalities
• Growth retardation

Tests are necessary to make the diagnosis of acrodermatitis enteropathica.

Tests that may be used to evaluate acrodermatitis enteropathica include:

• Alkaline phosphatase levels
• Serum zinc levels (usually low)
• Skin biopsy