The evaluation of acquired aplastic anemia begins with a careful history and physical examination. A history of chemical or drug exposures is very important.

Physical findings in those with acquired aplastic anemia may include:

• Pale skin
• Enlarged spleen
• Chest tenderness:
• Located over the sternum
• Rapid heart rate or irregular heartbeat

Tests are required to make the diagnosis of acquired aplastic anemia.

Tests that may be used to evaluate acquired aplastic anemia include:

• Bone marrow biopsy
• Complete blood count
• Platelet count
• Coagulation profile
• CT scan of the abdomen:
• to check size of spleen