The selective serotonin norepinephrine reuptake inhibitors (SSNRI) are a class of antidepressant medications that were developed after the selective serotonin reuptake inhibitors (SSRI). SSNRI medications inhibit both the reuptake of serotonin and norepinephrine in the synaptic space. This has the effect of increasing the concentration of both of these neurotransmitters, and ultimately, reducing depression.

Examples of SSNRI drugs include:

• Desvenlafaxine (Pristiq)
• Venlafaxine (Effexor)
• Duloxetine (Cymbalta)